Okadaic acid induces premature chromosome condensation reflecting the cell cycle progression in one-cell stage mouse embryos.

@article{Dyban1993OkadaicAI,
  title={Okadaic acid induces premature chromosome condensation reflecting the cell cycle progression in one-cell stage mouse embryos.},
  author={Andrei Dyban and Petra de Sutter and Yury Verlinsky},
  journal={Molecular reproduction and development},
  year={1993},
  volume={34 4},
  pages={402-15}
}
Haploid parthenogenetic embryos as well as fertilized mouse eggs were treated in vitro with 1-10 microM okadaic acid (OA) at the one-cell stage. Cytogenetic analysis detected that OA induces nuclear envelope breakdown (NEBD) and premature condensation of interphase chromosomes in pronuclei as well as in 2nd polar body (PB) nuclei. G1-, S-, and G2-type prematurely condensed chromosomes (PCC) were found in pronuclei of embryos of different age, which reflects their progression through the first… CONTINUE READING

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