Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue

@article{Gliksman1992OkadaicAI,
  title={Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue},
  author={Neal R. Gliksman and S F Parsons and Edward D. Salmon},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={119},
  pages={1271 - 1276}
}
We used high-resolution video microscopy to visualize microtubule dynamic instability in extracts of interphase sea urchin eggs and to analyze the changes that occur upon addition of 0.8-2.5 microM okadaic acid, an inhibitor of phosphatase 1 and 2A (PP1, PP2a) (Bialojan, D., and A. Takai. 1988. Biochem. J. 256:283-290). Microtubule plus-ends in these extracts oscillated between the elongation and shortening phases of dynamic instability at frequencies typical for interphase cells. Switching… CONTINUE READING

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