Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices.

@article{Harris1993OkadaicAI,
  title={Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices.},
  author={Kristina A. Harris and George A. Oyler and G M Doolittle and Inez Vincent and Ronald A Lehman and Randall L. Kincaid and Melvin L. Billingsley},
  journal={Annals of neurology},
  year={1993},
  volume={33 1},
  pages={77-87}
}
Hyperphosphorylated forms of the microtubule-associated protein tau are components of the paired helical filaments (PHFs) seen in patients with Alzheimer's disease. Slices of human lateral temporal cortex were obtained from tissues removed incidental to resections for intractable hippocampal epilepsy. Tau phosphorylation in temporal lobe slices was determined using mobility shifts after sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunodetection with the monoclonal antibodies… CONTINUE READING
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