Okadaic acid induced cyclin B1 expression and mitotic catastrophe in rat cortex

@article{Chen2006OkadaicAI,
  title={Okadaic acid induced cyclin B1 expression and mitotic catastrophe in rat cortex},
  author={Bo Chen and Min Cheng and Dao-jun Hong and Feng-Yan Sun and Min Zhu},
  journal={Neuroscience Letters},
  year={2006},
  volume={406},
  pages={178-182}
}
Accumulating evidence indicates that the aberrant re-entry of post-mitotic neurons into the G2/M phase of cell cycle and the resulting mitotic catastrophe may contribute to the pathogenesis of Alzheimer's disease. However, the cellular event that drives the differentiated neurons to abnormally enter G2/M phase remains elusive. Similarly, whether mitotic catastrophe is indeed one of the death pathways for differentiated neurons is not clear. Previous studies revealed that okadaic acid (OA), a… CONTINUE READING
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