Oil-in-water emulsion adjuvant with influenza vaccine in young children.

  title={Oil-in-water emulsion adjuvant with influenza vaccine in young children.},
  author={Timo Vesikari and Markus Knuf and Peter Wutzler and Aino V Karvonen and Dorothee Kieninger-Baum and H. J. Schmitt and Frank A Baehner and Astrid Borkowski and Theodore F. Tsai and Ralf L Clemens},
  journal={The New England journal of medicine},
  volume={365 15},
BACKGROUND The efficacy of inactivated influenza vaccines is known to be poor in infants and young children. METHODS We studied the effect of the adjuvant MF59, an oil-in-water emulsion, on the efficacy of trivalent inactivated influenza vaccine (TIV) in 4707 healthy children 6 to less than 72 months of age who had not previously been vaccinated against influenza. The children were randomly assigned to three study groups, each of which received the assigned vaccines in two doses, 28 days… CONTINUE READING