Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

@article{Alegria2017OhrPA,
  title={Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.},
  author={Thiago Geronimo Pires Alegria and Diogo A Meireles and Jos{\'e} Renato Cussiol and Mart{\'i}n Hugo and Madia Trujillo and Marcos Antonio de Oliveira and Sayuri Miyamoto and Raphael Ferreira Queiroz and Napole{\~a}o Fonseca Valadares and Richard Garratt and Rafael Radi and Paolo di Mascio and Ohara Augusto and Luis E S Netto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 2},
  pages={E132-E141}
}
Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active site of Ohr from Xylella fastidiosa and were efficiently reduced by the recombinant enzyme as assessed by a lipoamide-lipoamide dehydrogenase-coupled assay. Indeed, the rate constants between… CONTINUE READING
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