Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

  title={Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.},
  author={Thiago Geronimo Pires Alegria and Diogo A Meireles and Jos{\'e} Renato Cussiol and Mart{\'i}n Hugo and Madia Trujillo and Marcos Antonio de Oliveira and Sayuri Miyamoto and Raphael Ferreira Queiroz and Napole{\~a}o Fonseca Valadares and Richard Garratt and Rafael Radi and Paolo di Mascio and Ohara Augusto and Luis E S Netto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={114 2},
Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active site of Ohr from Xylella fastidiosa and were efficiently reduced by the recombinant enzyme as assessed by a lipoamide-lipoamide dehydrogenase-coupled assay. Indeed, the rate constants between… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
6 Extracted Citations
78 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 78 references

Structural insights into enzyme-substrate interaction and characterization of enzymatic intermediates of organic hydroperoxide resistance protein from Xylella fastidiosa

  • MA Oliveira
  • J Mol Biol
  • 2006
Highly Influential
11 Excerpts

Kinetic studies of peroxiredoxin 6 from Arenicola marina: Rapid oxidation by hydrogen peroxide and peroxynitrite but lack of reduction by hydrogen sulfide

  • E Loumaye
  • Arch Biochem Biophys 514(1-2):1–7
  • 2011
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…