Ohno's dilemma: evolution of new genes under continuous selection.

@article{Bergthorsson2007OhnosDE,
  title={Ohno's dilemma: evolution of new genes under continuous selection.},
  author={Ulfar Bergthorsson and Dan I Andersson and John R. Roth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={17004-9}
}
New genes with novel functions arise by duplication and divergence, but the process poses a problem. After duplication, an extra gene copy must rise to sufficiently high frequency in the population and remain free of common inactivating lesions long enough to acquire the rare mutations that provide a new selectable function. Maintaining a duplicated gene by selection for the original function would restrict the freedom to diverge. (We refer to this problem as Ohno's dilemma). A model is… CONTINUE READING
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