Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway

@inproceedings{Kim2017OhmyungsamycinsPA,
  title={Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway},
  author={Tae Sung Kim and Y H Shin and H J Lee and Jin Kyung Kim and Jin Ho Choe and Jichan Jang and Soohyun Um and Hyo Sun Jin and M. Asaliaru Komatsu and Guang-Ho Cha and Han-jung Chae and Dong-Chan Oh and Eun Kyeong Jo},
  booktitle={Scientific Reports},
  year={2017}
}
The induction of host cell autophagy by various autophagy inducers contributes to the antimicrobial host defense against Mycobacterium tuberculosis (Mtb), a major pathogenic strain that causes human tuberculosis. In this study, we present a role for the newly identified cyclic peptides ohmyungsamycins (OMS) A and B in the antimicrobial responses against Mtb infections by activating autophagy in murine bone marrow-derived macrophages (BMDMs). OMS robustly activated autophagy, which was… CONTINUE READING
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