Ohioensin F suppresses TNF-α-induced adhesion molecule expression by inactivation of the MAPK, Akt and NF-κB pathways in vascular smooth muscle cells.

@article{Byeon2012OhioensinFS,
  title={Ohioensin F suppresses TNF-α-induced adhesion molecule expression by inactivation of the MAPK, Akt and NF-κB pathways in vascular smooth muscle cells.},
  author={Hye-Eun Byeon and Sung Hee Um and Joung Han Yim and Hong Kum Lee and Suhkneung Pyo},
  journal={Life sciences},
  year={2012},
  volume={90 11-12},
  pages={396-406}
}
AIMS The expression of cell adhesion molecules on vascular smooth muscle cells is central to leukocyte recruitment and progression of atherosclerotic disease. Ohioensin F, a chemical compound of the Antarctic moss Polyerichastrum alpinum, exhibited inhibitory activity against protein tyrosine phosphatase 1B and antioxidant activity. However, published scientific information regarding other biological activities and pharmacological function of ohioensin F is scarce. In the present study, we… CONTINUE READING

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