Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.

@article{ODonnell2004OgtdependentXP,
  title={Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.},
  author={Niall O'Donnell and Natasha Elizabeth Zachara and Gerald W. Hart and Jamey D Marth},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 4},
  pages={1680-90}
}
The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viability, necessitating the use of conditional mutagenesis in vivo. We have extended these observations by segregating Ogt mutation to distinct somatic cell types, including neurons, thymocytes, and… CONTINUE READING

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