Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction.

@article{Koukkou1998OffspringON,
  title={Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction.},
  author={Eftychia Koukkou and Priya Ghosh and Clara Lowy and Lucilla Poston},
  journal={Circulation},
  year={1998},
  volume={98 25},
  pages={2899-904}
}
BACKGROUND Disturbances of the in utero environment may "program" for disease in later life. In this study, we determined whether dietary fat supplementation and/or diabetes in pregnancy can adversely affect vascular function in the offspring. METHODS AND RESULTS Female Sprague-Dawley rats were fed a breeding diet or a diet high in saturated fat (30% wt/wt) for 10 days before mating, throughout pregnancy, and postpartum. Endothelium-dependent relaxation to acetylcholine was blunted in… CONTINUE READING

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