Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

@article{Hayashi2012OffspringFO,
  title={Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice},
  author={Katsuhiko Hayashi and Sugako Ogushi and Kazuki Kurimoto and So Shimamoto and Hiroshi Ohta and Mitinori Saitou},
  journal={Science},
  year={2012},
  volume={338},
  pages={971 - 975}
}
Artificially Induced Oocytes In mice, male embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been shown to differentiate into primordial germ cell–like cells (PGCLCs) in vitro. Upon transplantation into testes, these PGCLCs can form fully functional sperm. Again working in mice, Hayashi et al. (p. 971, published online 4 October) found that female ESCs and iPSCs can also differentiate into PGCLCs, which, when aggregated in reconstituted ovaries, exhibited epigenetic… 

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