Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth.

@article{McGreal2012OffTA,
  title={Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth.},
  author={Eamon P. McGreal and Keziah Hearne and Owen B Spiller},
  journal={Immunobiology},
  year={2012},
  volume={217 2},
  pages={176-86}
}
Complement represents a keystone to the innate immune system, with three activation pathways that utilise foreign microbial pattern recognition as well as activation by the host's specific antibodies. However, innate immunity is not synonymous with neonatal immunity. The complement system in healthy term (38-42 weeks gestation) newborns is under-developed and, with only a few exceptions (e.g. C7 and factor D), the circulating complement component concentrations are between 10 and 80% of adult… CONTINUE READING
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