Off-the-shelf proteins that rival tailor-made antibodies as catalysts

  title={Off-the-shelf proteins that rival tailor-made antibodies as catalysts},
  author={Florian Hollfelder and Anthony J. Kirby and Dan S. Tawfik},
MIMICKING the efficiency of enzyme catalysis is a daunting challenge. An enzyme selectively binds and stabilizes the transition state(s) for a particular reaction1,2. Artificial host systems can bind ground states just as efficiently3, and rate enhancements comparable to those in enzymatic reactions can be achieved by bringing catalytic and substrate groups together in intramolecular reactions. But the combination of selective binding and efficient catalysis remains elusive. The best enzyme… CONTINUE READING

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