Off-the-shelf proteins that rival tailor-made antibodies as catalysts

@article{Hollfelder1996OfftheshelfPT,
  title={Off-the-shelf proteins that rival tailor-made antibodies as catalysts},
  author={Florian Hollfelder and Anthony J. Kirby and Dan S. Tawfik},
  journal={Nature},
  year={1996},
  volume={383},
  pages={60-63}
}
MIMICKING the efficiency of enzyme catalysis is a daunting challenge. An enzyme selectively binds and stabilizes the transition state(s) for a particular reaction1,2. Artificial host systems can bind ground states just as efficiently3, and rate enhancements comparable to those in enzymatic reactions can be achieved by bringing catalytic and substrate groups together in intramolecular reactions. But the combination of selective binding and efficient catalysis remains elusive. The best enzyme… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Transfecting pDNA to E. coli DH5α using bovine serum albumin nanoparticles as a delivery vehicle.

Luminescence : the journal of biological and chemical luminescence • 2015
View 1 Excerpt

The role of reorganization energy in rational enzyme design.

Current opinion in chemical biology • 2014
View 1 Excerpt

Are Molecular Alphabets Universal Enabling Factors for the Evolution of Complex Life?

Origins of Life and Evolution of Biospheres • 2013
View 2 Excerpts

Similar Papers

Loading similar papers…