Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events.

Abstract

Sulforaphane is a naturally occurring isothiocyanate in cruciferous vegetables. Sulforaphane inhibits histone deacetylases, leading to the transcriptional activation of genes including tumor suppressor genes. The compound has attracted considerable attention in the chemoprevention of prostate cancer. Here we tested the hypothesis that sulforaphane is not… (More)
DOI: 10.1016/j.jnutbio.2014.02.007

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