Off-label use of rituximab in 196 patients with severe, refractory systemic autoimmune diseases.

@article{RamosCasals2010OfflabelUO,
  title={Off-label use of rituximab in 196 patients with severe, refractory systemic autoimmune diseases.},
  author={Manuel Ramos-Casals and Francisco Javier Garc{\'i}a-Hern{\'a}ndez and Enrique de Ram{\'o}n and Jos{\'e} Luis Callejas and Agust{\'i}n Mart{\'i}nez-Berriotxoa and Lucio Pallar{\'e}s and Luis Caminal-Montero and Albert Selva-O'Callaghan and Joaquim Oristrell and Carlota Hidalgo and Roberto P{\'e}rez-{\'A}lvarez and Mar{\'i}a Luisa Mic{\'o} and Francisco Javier Enr{\'i}quez Medrano and Ricardo G{\'o}mez de la Torre and C{\'a}ndido D{\'i}az-Lagares and M. Ferrer Camps and Norberto Ortego and Julio S{\'a}nchez-Rom{\'a}n},
  journal={Clinical and experimental rheumatology},
  year={2010},
  volume={28 4},
  pages={
          468-76
        }
}
OBJECTIVES To analyse the safety and efficacy of the off-label use of rituximab in patients with severe, refractory systemic autoimmune diseases. METHODS In 2006, the Study Group on Autoimmune Diseases of the Spanish Society of Internal Medicine created the BIOGEAS project, a multicenter study devoted to collecting data on the use of biological agents in adult patients with systemic autoimmune diseases refractory to standard therapies (failure of at least two immunosuppressive agents… CONTINUE READING

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