Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children.

@article{Young2009OfflabelUO,
  title={Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children.},
  author={Guy Aaron Young and Brian M Wicklund and Philip Neff and Chelsea Johnson and Diane Jean Nugent},
  journal={Pediatric blood & cancer},
  year={2009},
  volume={53 2},
  pages={179-83}
}
BACKGROUND Recombinant factor VIIa is a general hemostatic agent. Randomized trials have demonstrated effectiveness in adults; however, data in children are confined to case reports and series subject to publication bias. PROCEDURES A consecutive cohort of children treated with rFVIIa was identified via inspection of pharmacy records. Data collected included demographic data, underlying disorders, reason for rFVIIa use, dosing, thrombotic events, and mortality. Efficacy was scored… CONTINUE READING

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Unlabeled uses of factor VIIa (recombinant) in pediatric patients.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists • 2010
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