Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.

@article{Lamprecht2005OffBT,
  title={Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.},
  author={P. N. Lamprecht},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={141 2},
  pages={
          201-10
        }
}
There is substantial evidence that T-cells are off balance in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Genetic risk factors may influence shaping of the TCR repertoire and regulatory control of T-cells in predisposed individuals. T-cells are found in inflammatory lesions. Vigorous Th1-type responses are seen in Wegener's granulomatosis and microscopic angiitis, whereas a Th2-type response predominates in Churg-Strauss syndrome. Oligoclonality and shortened telomers… CONTINUE READING
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