Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast

@article{Ericson2008OffTargetEO,
  title={Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast},
  author={Elke Ericson and Marinella Gebbia and Lawrence E. Heisler and Jan Wildenhain and Mike Tyers and Guri Giaever and Corey Nislow},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={5 - 11}
}
To better understand off-target effects of widely prescribed psychoactive drugs, we performed a comprehensive series of chemogenomic screens using the budding yeast Saccharomyces cerevisiae as a model system. Because the known human targets of these drugs do not exist in yeast, we could employ the yeast gene deletion collections and parallel fitness profiling to explore potential off-target effects in a genome-wide manner. Among 214 tested, documented psychoactive drugs, we identified 81… CONTINUE READING

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