Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance

Abstract

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome. Development of severe mitochondrial toxicity has been well documented in patients infected with HIV and administered NRTIs. In vitro biochemical experiments have demonstrated that the… (More)
DOI: 10.3389/fmolb.2017.00074

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