Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms.

@article{Stehle2001OfRA,
  title={Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms.},
  author={J{\"o}rg H. Stehle and Charlotte von Gall and Christof Schomerus and H. W. Korf},
  journal={Journal of biological rhythms},
  year={2001},
  volume={16 4},
  pages={312-25}
}
Melatonin synthesis in the mammalian pineal gland is one of the best investigated output pathways of the circadian clock because it can be readily measured and is tightly regulated by a clearly defined input, the neurotransmitter norepinephrine. In this system, a regulatory scenario was deciphered that is centered around the cyclic AMP pathway but shows peculiar species-specific differences. In rodents, the cyclic AMP-mediated, temporally sequential up-regulation of two transcription factors… CONTINUE READING

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