Of mice and man: TLR11 (finally) finds profilin.

  title={Of mice and man: TLR11 (finally) finds profilin.},
  author={Fanny N. Lauw and Daniel R. Caffrey and Douglas T Golenbock},
  journal={Trends in immunology},
  volume={26 10},
Toll-like receptors (TLRs) are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli. The first defined ligand for TLR11 has now been described as a profilin-like protein from Toxoplasma gondii. This discovery potentially gives us important clues as to how a gene expressed in mice, but not humans, actually… CONTINUE READING

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