Of mice, flies – and men? Comparing fungal infection models for large-scale screening efforts

@inproceedings{Brunke2015OfMF,
  title={Of mice, flies – and men? Comparing fungal infection models for large-scale screening efforts},
  author={Sascha Brunke and Jessica Quintin and Lydia Kasper and Ilse D Jacobsen and Martin Ernst Richter and Ekkehard Hiller and Tobias Schwarzmueller and Christophe d'Enfert and Karl Kuchler and Steffen Rupp and Bernhard Hube and Dominique Ferrandon},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Studying infectious diseases requires suitable hosts for experimental in vivo infections. Recent years have seen the advent of many alternatives to murine infection models. However, the use of non-mammalian models is still controversial because it is often unclear how well findings from these systems predict virulence potential in humans or other mammals. Here, we compare the commonly used models, fruit fly and mouse (representing invertebrate and mammalian hosts), for their similarities and… CONTINUE READING
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