Of flies and man: Drosophila as a model for human complex traits.

@article{Mackay2006OfFA,
  title={Of flies and man: Drosophila as a model for human complex traits.},
  author={Trudy F C Mackay and Robert R. H. Anholt},
  journal={Annual review of genomics and human genetics},
  year={2006},
  volume={7},
  pages={339-67}
}
Understanding the genetic and environmental factors affecting human complex genetic traits and diseases is a major challenge because of many interacting genes with individually small effects, whose expression is sensitive to the environment. Dissection of complex traits using the powerful genetic approaches available with Drosophila melanogaster has provided important lessons that should be considered when studying human complex traits. In Drosophila, large numbers of pleiotropic genes affect… CONTINUE READING

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