Of fat, β cells, and diabetes.


The molecular mechanisms linking diet, obesity, and type 2 diabetes are still poorly understood. In a recent paper, Ohtsubo et al. (2011) show that high lipid levels induce nuclear exclusion of Foxa2 and HNF1α in β cells, leading to impaired expression and glycosylation of proteins controlling glucose-stimulated insulin secretion.

DOI: 10.1016/j.cmet.2011.09.006

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@article{Thorens2011OfF, title={Of fat, β cells, and diabetes.}, author={Bernard Thorens}, journal={Cell metabolism}, year={2011}, volume={14 4}, pages={439-40} }