Of fat, β cells, and diabetes.

Abstract

The molecular mechanisms linking diet, obesity, and type 2 diabetes are still poorly understood. In a recent paper, Ohtsubo et al. (2011) show that high lipid levels induce nuclear exclusion of Foxa2 and HNF1α in β cells, leading to impaired expression and glycosylation of proteins controlling glucose-stimulated insulin secretion.

DOI: 10.1016/j.cmet.2011.09.006

1 Figure or Table

Statistics

0200400600201220132014201520162017
Citations per Year

209 Citations

Semantic Scholar estimates that this publication has 209 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Thorens2011OfF, title={Of fat, β cells, and diabetes.}, author={Bernard Thorens}, journal={Cell metabolism}, year={2011}, volume={14 4}, pages={439-40} }