Of Mice and Women: Light as a Circadian Stimulus in Breast Cancer Research

  title={Of Mice and Women: Light as a Circadian Stimulus in Breast Cancer Research},
  author={John D. Bullough and Mark S. Rea and Mariana G. Figueiro},
  journal={Cancer Causes \& Control},
ObjectiveNocturnal rodents are frequently used as models in human breast cancer research, but these species have very different visual and circadian systems and, therefore, very different responses to optical radiation or, informally, light. Because of the impact of light on the circadian system and because recent evidence suggests that cancer risk might be related to circadian disruption, it is becoming increasingly clear that optical radiation must be properly characterized for both nocturnal… 
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  • M. Figueiro
  • Biology, Psychology
    Current Sleep Medicine Reports
  • 2017
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Support has developed for a possible role of “circadian disruption,” particularly from an altered-lighted environment (such as light at night), which may increase breast cancer risk through several mechanisms, including increased estrogen production and altered estrogen receptor function.
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