Of Mice and Not Men: Differences between Mouse and Human Immunology

@article{Mestas2004OfMA,
  title={Of Mice and Not Men: Differences between Mouse and Human Immunology},
  author={Javier Mestas and Christopher C W Hughes},
  journal={The Journal of Immunology},
  year={2004},
  volume={172},
  pages={2731 - 2738}
}
Mice are the experimental tool of choice for the majority of immunologists and the study of their immune responses has yielded tremendous insight into the workings of the human immune system. However, as 65 million years of evolution might suggest, there are significant differences. Here we outline known discrepancies in both innate and adaptive immunity, including: balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR… Expand
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References

SHOWING 1-10 OF 112 REFERENCES
T-Cell receptor αβ and γδ T cells in rat and human skin — are they equivalent?
TLDR
The purpose of this review is to fill gaps in the understanding of the relationship of rodent skin T cells to T cells identified in human skin and the normal physiologic and pathologic role(s) of these cells. Expand
Human TH1 and TH2 subsets: doubt no more.
TLDR
It appears that key functional events are emerging in the pathogenesis of HIV-1 infection leading to AIDS and that monitoring of these events is practical; there is a sense of urgency about these studies: they hold clues for the diagnosis, prevention and therapy of AIDS. Expand
Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*
TLDR
It is demonstrated that species-specific differences in tissue expression and responses to lipopolysaccaride (LPS) coincide with the presence of different, evolutionary non-conserved promoter sequences in both species, which suggests a role of TLR3 in innate and adaptive immune responses to viral infections. Expand
CD28/B7 system of T cell costimulation.
TLDR
This review summarizes the state of CD28/B7 immunobiology both in vitro and in vivo; summarizes the many experiments that have led to the current understanding of the participants in this complex receptor/ligand system; and illustrates the current models for CD28-mediated T cell and B cell regulation. Expand
Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
TLDR
In analyzing type I interferon signaling, a difference between murine and human cells is uncovered which may affect how these two species control linkage between innate and adaptive immunity. Expand
ICOS is essential for effective T-helper-cell responses
TLDR
In vivo genetic evidence is provided that ICOS delivers a co-stimulatory signal that is essential both for efficient interaction between T and B cells and for normal antibody responses to T-cell-dependent antigens. Expand
Delayed hypersensitivity in the mouse.
TLDR
This chapter discusses the delayed-type hypersensitivity (DTH), the prototype model of cellular immune phenomena as it occurs in mice, the most likely subject for studying the pathogenetic roles of DTH in infectious disease. Expand
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
TLDR
A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20–27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses. Expand
A Subtle Role for Cd2 in T Cell Antigen Recognition
TLDR
It is demonstrated that T cells from CD2-deficient mice have a quantitative defect in antigen recognition: they require a higher concentration of antigen to produce the same response as wild-type T cells. Expand
ICOS is critical for CD40-mediated antibody class switching
TLDR
Mice lacking ICOS exhibit profound deficits in immunoglobulin isotype class switching, accompanied by impaired germinal centre formation, and class switching was restored in ICOS-/- mice by CD40 stimulation, showing that ICOS promotes T-cell/B-cell collaboration through the CD40/CD40L pathway. Expand
...
1
2
3
4
5
...