Of ITAMs and ITIMs: turning on and off the B cell antigen receptor

@article{Thomas1995OfIA,
  title={Of ITAMs and ITIMs: turning on and off the B cell antigen receptor },
  author={Matthew L. Thomas},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={1953 - 1956}
}
F or any given receptor, there are mechanisms that regulate the activation of signal transduction pathways, as well as mechanisms that extinguish those signaling pathways. Responding to environmental signals requires that both positive and negative regulation proceed in an ordered manner. Much research has focused on lymphocyte antigen receptor-induced signal transduction pathways, and an understanding of some of the initial events has been gained. The mechanisms that terminate signaling are… CONTINUE READING