Oestrogenic activity of parabens in MCF7 human breast cancer cells

@article{Byford2002OestrogenicAO,
  title={Oestrogenic activity of parabens in MCF7 human breast cancer cells},
  author={J R Byford and L. E. Shaw and Michael G. B. Drew and G. S. Pope and Maurice J. Sauer and Philippa D Darbre},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2002},
  volume={80},
  pages={49-60}
}
  • J. Byford, L. Shaw, +3 authors P. Darbre
  • Published 2002
  • Medicine, Chemistry
  • The Journal of Steroid Biochemistry and Molecular Biology
Parabens (4-hydroxybenzoic acid esters) have been recently reported to have oestrogenic activity in yeast cells and animal models. Since the human population is exposed to parabens through their widespread use as preservatives in foods, pharmaceuticals and cosmetics, we have investigated here whether oestrogenic activity of these compounds can also be detected in oestrogen-sensitive human cells. We report on the oestrogenic effects of four parabens (methylparaben, ethylparaben, n-propylparaben… Expand
Oestrogenic activity of isobutylparaben in vitro and in vivo
TLDR
Results here show that branching of the alkyl chain to isobutylparaben increases oestrogenic activity beyond that of the equivalent length linear alkyL chain in n‐butyl paraben. Expand
Oestrogenic activity of p‐hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines
TLDR
It can be concluded that removal of the ester group from parabens does not abrogate its oestrogenic activity and that p‐hydroxybenzoic acid can give oestrogensic responses in human breast cancer cells. Expand
Oestrogenic activity of benzyl salicylate , benzyl benzoate and butylphenylmethylpropional ( Lilial ) in MCF 7 human breast cancer cells in vitro
Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) are added to bodycare cosmetics used around the human breast. We report here that all three compounds possess oestrogenicExpand
Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro
TLDR
Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional are further chemical components of cosmetic products which give oestrogenic responses in a human breast cancer cell line in culture. Expand
Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF‐7 human breast cancer cells
TLDR
It is demonstrated that parabens, either alone or in combination, are present in human breast tissue at concentrations sufficient to stimulate the proliferation of MCF‐7 cells in vitro, and that functional consequences of the presence of paraben inhuman breast tissue should be assessed on the basis of all five parabEN and not single parabened individually. Expand
Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells
TLDR
Seven of the eight phytoestrogens (all except resveratrol) gave similar maximal responses to that given by 17beta-oestradiol in cell-based assays, and the most marked difference was for coumestrol and 8-prenylnaringenin which both displayed a relatively potent ability to displace [3H]oest radiol from cytosolic ER compared with their much lower activity in the cell- based assays. Expand
Oestrogenic and androgenic activity of triclosan in breast cancer cells
TLDR
It is reported here that triclosan possesses intrinsic oestrogenic and androgenic activity in a range of assays in vitro which could provide some explanation for the endocrine disrupting properties described in aquatic populations. Expand
Oestrogenic activity of benzylparaben
TLDR
It is demonstrated that the oestrogenicity of methylparaben can be increased by the addition of an aryl group as well as by lengthening or branching the alkyl grouping. Expand
p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells.
TLDR
The higher stability of parabens may explain their accumulation in breast cancer tissue as previously reported in the literature. Expand
Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells
TLDR
The effects of monosulphation on the oestrogen agonist properties of these three phytoestrogens in MCF-7 human breast cancer cells are described in terms of their relative ability to compete with [3H]oestradiol for binding to ostrogen receptor (ER), to induce a stably transfected oestrogens-responsive reporter gene (ERE-CAT) and to stimulate cell growth. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic.
TLDR
Findings from in vitro and in vivo studies which confirm that a range of alkyl hydroxy benzoate preservatives (parabens) are weakly estrogenic are reported, suggesting that the safety in use of these chemicals should be reassessed. Expand
Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays.
  • A. Hossaini, J. Larsen, J. Larsen
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2000
TLDR
In immature Wistar rats, subcutaneous administration of butyl p-hydroxybenzoate produced a weak oestrogenic response at 600mg/kg body weight per day, while in immature B6D2F1 mice, this effect was not considered. Expand
Environmentally persistent alkylphenolic compounds are estrogenic.
TLDR
It is shown that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals and capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines. Expand
Effects of oestrogen on human breast cancer cells in culture
Oestrogen regulates the growth of human breast cancer cell lines ZR-75–1, T-47-D and MCF-7 (KO and McGrath). Basal cell growth can be reduced (T-47-D) or eliminated (ZR-75–1) by prior growth in theExpand
Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells
TLDR
C cultured RUCA-I cells represent a valuable endometrial derived model system to assess the relative potencies and the molecular mode of action of environmental estrogens in vitro and will provide tools to study the activity of xenoestrogens in vivo and thus carry risk assessment one step further. Expand
3,5,3′,5′-Tetrachlorobiphenyl is a weak oestrogen agonist in vitro and in vivo
TLDR
It is demonstrated that 3,4,3',4'-tetrachlorobiphenyl (PCB 80) can be considered to be a weak oestrogen agonist, but the 2,5,2',5'-congener ( PCB 52) revealed no oestrogensic properties in any of these assays. Expand
Estrogenic effects of p-hydroxybenzoic acid in CD1 mice.
TLDR
The estrogenic activity of p-hydroxybenzoic acid (PHBA), a compound related to a commonly used group of preservatives in food, cosmetic, and pharmaceutical preparations, was evaluated with immature and adult ovariectomized female mice (CD1) using two well-known bioassays. Expand
Molecular structure in relation to oestrogenic activity. Compounds without a phenanthrene nucleus
In earlier publications the oestrogenic activity of a number of synthetic substances has been discussed. The first compounds to be tested contained the phenanthrene ring system, and it was shownExpand
3,4,3',4'-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo.
TLDR
It is demonstrated that 3,4,3',4'-tetrachlorobiphenyl (TCB) (PCB77) can be included in the increasing list of environmental pollutants that possess the ability to mimic estrogen action and be termed an environmental estrogen. Expand
Interaction of phenol red with estrogenic and antiestrogenic action on growth of human breast cancer cells ZR-75-1 and T-47-D.
Studies reported here confirm that the pH indicator, phenol red, acts as a weak estrogen and reexamine the significance of estrogenic and antiestrogenic effects on growth of the human breast cancerExpand
...
1
2
3
4
5
...