Oestrogenic activity of parabens in MCF7 human breast cancer cells

@article{Byford2002OestrogenicAO,
  title={Oestrogenic activity of parabens in MCF7 human breast cancer cells},
  author={Jt Byford and Lesley E. Shaw and Michael G. B. Drew and G. S. Pope and Maurice J. Sauer and Philippa D Darbre},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2002},
  volume={80},
  pages={49-60}
}
  • J. ByfordL. Shaw P. Darbre
  • Published 31 January 2002
  • Biology, Medicine, Chemistry
  • The Journal of Steroid Biochemistry and Molecular Biology

Oestrogenic activity of isobutylparaben in vitro and in vivo

Results here show that branching of the alkyl chain to isobutylparaben increases oestrogenic activity beyond that of the equivalent length linear alkyL chain in n‐butyl paraben.

Oestrogenic activity of p‐hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines

It can be concluded that removal of the ester group from parabens does not abrogate its oestrogenic activity and that p‐hydroxybenzoic acid can give oestrogensic responses in human breast cancer cells.

Oestrogenic activity of benzyl salicylate , benzyl benzoate and butylphenylmethylpropional ( Lilial ) in MCF 7 human breast cancer cells in vitro

Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional are further chemical components of cosmetic products which give oestrogenic responses in a human breast cancer cell line in culture.

Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro

Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional are further chemical components of cosmetic products which give oestrogenic responses in a human breast cancer cell line in culture.

Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF‐7 human breast cancer cells

It is demonstrated that parabens, either alone or in combination, are present in human breast tissue at concentrations sufficient to stimulate the proliferation of MCF‐7 cells in vitro, and that functional consequences of the presence of paraben inhuman breast tissue should be assessed on the basis of all five parabEN and not single parabened individually.

Oestrogenic and androgenic activity of triclosan in breast cancer cells

It is reported here that triclosan possesses intrinsic oestrogenic and androgenic activity in a range of assays in vitro which could provide some explanation for the endocrine disrupting properties described in aquatic populations.

Oestrogenic activity of benzylparaben

It is demonstrated that the oestrogenicity of methylparaben can be increased by the addition of an aryl group as well as by lengthening or branching the alkyl grouping.

p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells.

Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells

The effects of monosulphation on the oestrogen agonist properties of these three phytoestrogens in MCF-7 human breast cancer cells are described in terms of their relative ability to compete with [3H]oestradiol for binding to ostrogen receptor (ER), to induce a stably transfected oestrogens-responsive reporter gene (ERE-CAT) and to stimulate cell growth.
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