Oestrogenic activity of isobutylparaben in vitro and in vivo.

  title={Oestrogenic activity of isobutylparaben in vitro and in vivo.},
  author={Philippa D Darbre and Jovan Byford and L E Shaw and Robert A Horton and Greg S. Pope and Maurice J. Sauer},
  journal={Journal of applied toxicology : JAT},
  volume={22 4},
The alkyl esters of p-hydroxybenzoic acid (parabens) are used widely as preservatives in foods, pharmaceuticals and cosmetics to which the human population is exposed. Recent studies have reported that methylparaben, ethylparaben, n-propylparaben and n-butylparaben all possess oestrogenic activity in several in vitro assays and in animal models in vivo. This study reports on the oestrogenic activity of isobutylparaben in a panel of assays in vitro and in vivo. Isobutylparaben was able to… CONTINUE READING
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