Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha.

@article{Ren2010OestrogenRP,
  title={Oestrogen regulates proliferation and differentiation of human islet-derived precursor cells through oestrogen receptor alpha.},
  author={Zhenhua Ren and Chunlin Zou and Huijun Ji and Y Alex Zhang},
  journal={Cell biology international},
  year={2010},
  volume={34 5},
  pages={523-30}
}
E2 (oestradiol-17beta) is an important hormone that regulates various cell functions including insulin production. hIPCs (human islet-derived precursor cells) are capable of proliferating and differentiating into cells that secrete insulin in response to glucose in vivo and in vitro. However, the effect of E2 on hIPCs is currently unclear. In this study, we found that ERalpha (oestrogen receptor alpha), but not ERbeta, was expressed on hIPCs, and E2 promoted the proliferation and inhibited the… CONTINUE READING
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