Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis.

@article{Shupnik2002OestrogenRR,
  title={Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis.},
  author={Margaret A. Shupnik},
  journal={Journal of neuroendocrinology},
  year={2002},
  volume={14 2},
  pages={85-94}
}
Information on oestrogen action has grown exponentially in the past decade, and recent studies have begun to define the mechanism of ligand-dependent activation and cell-specific effects. Oestrogen-mediated gene transcription in a specific tissue depends on several factors, the most important of which is the presence of at least one of the two nuclear oestrogen receptor (ER) isoforms, ER(alpha) and ERbeta. The presence and levels of specific ER isoform variants, along with receptor coactivator… CONTINUE READING

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