Oestrogen-receptor status and endocrine therapy of breast cancer: response rates and status stability.

Abstract

The concentration of cellular oestrogen receptor (RE) was measured in both the soluble and nuclear-pellet fractions of biopsies from 1,000 breast cancers. Data suggest that functional steroid RE is always in equilibrium between the soluble and nuclear fractions. However, biopsies from only one-third of patients contained detectable amounts of high-affinity… (More)
DOI: 10.1038/bjc.1981.8

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