Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.

@article{Hewitt2003OestrogenRK,
  title={Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.},
  author={Sylvia C Hewitt and Kenneth S. Korach},
  journal={Reproduction},
  year={2003},
  volume={125 2},
  pages={143-9}
}
Oestrogen is an essential component of female reproduction, with well-characterized functions in the uterus, ovaries, mammary gland and hypothalamic-pituitary axis. The mechanism of oestrogen action involves mediation of the rate of transcription by nuclear-localized oestrogen receptor molecules. Two oestrogen receptors are present in mouse tissues, oestrogen receptors alpha and beta. Each receptor exhibits differential tissue expression patterns. Mouse models with genetically engineered… CONTINUE READING