Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study

@article{Wedrn2004OestrogenR,
  title={Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study},
  author={Sara Wedr{\'e}n and Lovisa Lovmar and Keith N Humphreys and Cecilia MK Magnusson and H{\aa}kan Melhus and Ann-Christine Syv{\"a}nen and Andreas Kindmark and Ulf Landegren and Maria Lagerstr{\"o}m Ferm{\'e}r and Fredrik Stiger and Ingemar Persson and John Baron and Elisabete Weiderpass},
  journal={Breast Cancer Research},
  year={2004},
  volume={6},
  pages={R437 - R449}
}
Oestrogen receptor α, which mediates the effect of oestrogen in target tissues, is genetically polymorphic. Because breast cancer development is dependent on oestrogenic influence, we have investigated whether polymorphisms in the oestrogen receptor α gene (ESR1) are associated with breast cancer risk. We genotyped breast cancer cases and age-matched population controls for one microsatellite marker and four single-nucleotide polymorphisms (SNPs) in ESR1. The numbers of genotyped cases and… CONTINUE READING