Oestrogen induced downregulation of TFPI expression is mediated by ERα.

Abstract

INTRODUCTION Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. Moreover, reduced TFPI levels have been reported in plasma… (More)
DOI: 10.1016/j.thromres.2014.04.004

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