Oestrogen attenuates tumour progression in hepatocellular carcinoma.

  title={Oestrogen attenuates tumour progression in hepatocellular carcinoma.},
  author={Hanwen Xu and Yinna Wei and Yu Zhang and Yichen Xu and Feng Li and Jing Liu and Wei Zhang and Xiaodong Han and Ren Xiang Tan and Pingping Shen},
  journal={The Journal of pathology},
  volume={228 2},
The precise mechanisms underlying gender disparity in hepatocellular carcinoma (HCC) progression and prognosis are not understood. We demonstrate that oestrogen attenuates HCC progression in vitro and in vivo, and this may contribute to the gender differences in HCC behaviour. To investigate the role of oestrogen in HCC progression, we developed an orthotopic homograft tumour model by liver implantation of H22 cells. In combination with male castration, female ovariectomy, and oestrogen… CONTINUE READING
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