Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset

@article{Stimson1988OestrogenAH,
  title={Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset},
  author={William H. Stimson},
  journal={Scandinavian Journal of Immunology},
  year={1988},
  volume={28}
}
  • W. Stimson
  • Published 1988
  • Biology, Medicine
  • Scandinavian Journal of Immunology
Human spleen cells were investigated for specific oestrogen binding using oestradiol‐17β. High affinity, low capacity binding was observed (Kd=2.5±10−10m) and the characteristics of the oestrogen receptor identified were typical of this type of species. T lymphocyte subpopulations were prepared by negative selection by means of the monoclonal antibodies Leu 2a and 3a. Oestrogen receptors were only found in T cells of the suppressor/cytotoxic (CD8‐positive) subset while helper/inducer… Expand
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