Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset

@article{Stimson1988OestrogenAH,
  title={Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset},
  author={William H. Stimson},
  journal={Scandinavian Journal of Immunology},
  year={1988},
  volume={28}
}
  • W. Stimson
  • Published 1 September 1988
  • Biology, Medicine
  • Scandinavian Journal of Immunology
Human spleen cells were investigated for specific oestrogen binding using oestradiol‐17β. High affinity, low capacity binding was observed (Kd=2.5±10−10m) and the characteristics of the oestrogen receptor identified were typical of this type of species. T lymphocyte subpopulations were prepared by negative selection by means of the monoclonal antibodies Leu 2a and 3a. Oestrogen receptors were only found in T cells of the suppressor/cytotoxic (CD8‐positive) subset while helper/inducer… 

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References

SHOWING 1-10 OF 46 REFERENCES

The oestrogen antagonists, tamoxifen and FC-1157a, display oestrogen like effects on human lymphocyte functions in vitro.

TLDR
It is concluded that the anti-oestrogens display an effect on the functions of human lymphocytes similar to that previously reported for oestradiol.

An investigation into the immunosuppressive properties of oestrogen.

TLDR
It appears that estrogen caused both decreased T lymphocyte response and enhanced B lymphocyte activity resulting in increased expression of related markers in rats treated with estrogen.

Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells.

TLDR
The restriction of estrogen receptors to T cells bearing the "suppressor-cytotoxic" phenotype suggests a possible pathway for the modulation of T cell suppressive activities by estrogens.

Effects of steroids on the secretion of immunoregulatory factors by thymic epithelial cell cultures.

TLDR
This study supports the idea that certain steroids can influence the immune response indirectly through the thymus through the effects of dose dependent steroids.

Androgen binding cytosol receptors in the rat thymus: physicochemical properties, specificity and localisation.

TLDR
Normal rat-thymus cytosol was shown to contain a 5 alpha-dihydrotestosterone-binding species characterised by low capacity and high affinity, which supports the idea that the thymus is an androgen-responsive tissue and that at least part of the immunoregulatory effects of androgens are mediated through theThymus.

Androgen binding cytosol receptors in the rat thymus: physicochemical properties, specificity and localisation.

TLDR
The thymus was not found to be capable of 5 alpha-reduction; unlike the prostate, it rapidly metabolised testosterone to androstenedione and the idea that theThymus is an androgen-responsive tissue and that at least part of the immunoregulatory effects of androgens are mediated through the thymos is supported.

Nuclear glucocorticoid binding in chronic lymphatic leukemia lymphocytes.

TLDR
Using this method, specific nuclear glucocorticoid binding was demonstrated in 14/14 patients with untreated CLL and no correlation was found between levels of nuclear-associated 3H-TA and peripheral white blood cell count or rosetting ability of circulating lymphocytes.