Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention?

@article{Hamersvelt1996OedemaFW,
  title={Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention?},
  author={H. V. van Hamersvelt and H. Kloke and D. D. de Jong and Robert A. R Koene and F. Huysmans},
  journal={Journal of Hypertension},
  year={1996},
  volume={14},
  pages={1041–1046}
}
Objective To determine whether the common side effect of ankle oedema with arteriolar vasodilators such as the calcium entry blocker (CEB) nifedipine and the potassium channel opener (PCO) diazoxide is the direct result of peripheral vasodilation or merely a consequence of renal sodium retention. Design In 12 healthy sitting volunteers we studied for 3 h the effects of 20 mg nifedipine, 150 mg diazoxide intravenously, 25 mg captopril and placebo on oedema formation and sodium excretion… Expand
Ankle Oedema and Sympathetic Activation
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