Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons.

@article{Moon1999OdorantsIT,
  title={Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons.},
  author={C Preston Moon and Young Kwan Sung and Rahul Reddy and Gabriele V. Ronnett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 25},
  pages={14605-10}
}
Although odorants are known to activate olfactory receptor neurons through cAMP, the long-term effects of odorant detection are not known. Our recent findings indicate that there is also a delayed and sustained cAMP response, with kinetics sufficient to mediate long-term cellular responses. This cAMP response is mediated by cGMP through activation of adenylyl cyclase by protein kinase G (PKG). Therefore, we investigated the ability of odorants to regulate gene expression in rat olfactory… CONTINUE READING
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