Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm

@article{Spehr2006OdorantRA,
  title={Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm},
  author={Marc Spehr and Katlen Schwane and Jeffrey A. Riffell and Richard K. Zimmer and Hanns Hatt},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={250},
  pages={128-136}
}
Since their discovery in 1991, members of the odorant receptor (OR) family have been found in various ectopic tissues, including testis and sperm. It took, however, more than a decade for the first mammalian testicular ORs to be functionally characterized and implicated in a reproductively relevant scenario. Activation of hOR17-4 and mOR23 in human and mouse sperm, respectively, mediates distinct flagellar motion patterns and chemotactic behavior in various bioassays. For hOR17-4, receptor… 
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Methods used to measure sperm chemotaxis are reviewed and recent studies of allurin, a 21-kDa protein belonging to the Cysteine-RIch Secretory Protein (CRISP) family that has chemoattraction activity for both amphibian and mammalian sperm are focused on.
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It is revealed that different ORs perform diverse functions in cutaneous cells, and thus offering an approach for the modulated treatment of skin diseases and wound repair.
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