Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia

@article{Ishikawa2005Odf2deficientMC,
  title={Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia},
  author={Hiroaki Ishikawa and Akiharu Kubo and Shoichiro Tsukita and Sachiko Tsukita},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={517-524}
}
Outer dense fibre 2 (Odf2; also known as cenexin) was initially identified as a main component of the sperm tail cytoskeleton, but was later shown to be a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Here we show that Odf2 expression is suppressed in mouse F9 cells when both alleles of Odf2 genes are deleted. Unexpectedly, the cell cycle of Odf2−/− cells does not seem to be affected. Immunofluorescence and ultrathin-section… Expand

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