Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia

  title={Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia},
  author={H. Ishikawa and A. Kubo and S. Tsukita},
  journal={Nature Cell Biology},
  • H. Ishikawa, A. Kubo, +1 author S. Tsukita
  • Published 2005
  • Medicine, Biology
  • Nature Cell Biology
  • Outer dense fibre 2 (Odf2; also known as cenexin) was initially identified as a main component of the sperm tail cytoskeleton, but was later shown to be a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Here we show that Odf2 expression is suppressed in mouse F9 cells when both alleles of Odf2 genes are deleted. Unexpectedly, the cell cycle of Odf2−/− cells does not seem to be affected. Immunofluorescence and ultrathin-section… CONTINUE READING

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