Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment.

  title={Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment.},
  author={Sandip Shaunak and Richard W. Orrell and Eoin O'Sullivan and Malcolm B. Hawken and Russell J M Lane and Leslie J Henderson and Christopher Kennard},
  journal={Annals of neurology},
  volume={38 1},
Saccadic eye movements, fixation, and smooth pursuit were recorded in 17 subjects with amyotrophic lateral sclerosis (ALS) and 11 age-matched controls using a magnetic scleral search coil. Reflexive, remembered and antisaccades, and smooth pursuit at four target velocities were studied. Subjects with ALS showed significantly elevated error rates (distractibility) and latency in the antisaccade and remembered saccade paradigms but no abnormality of reflexive saccades. The frequency of small… CONTINUE READING

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