Ocular toxicology: the Draize eye test

  title={Ocular toxicology: the Draize eye test},
  author={Antonio Secchi and Velika Deligianni},
  journal={Current Opinion in Allergy and Clinical Immunology},
Purpose of review Superficial ocular tissues are frequently exposed to damage produced by chemical compounds applied on or around the ocular surface for cosmetic, therapeutic or accidental reasons. An experimental test measuring objectively and in a reproducible way any potential damaging effect would certainly help in prospectively minimizing unwanted effects. The Draize eye test, although commonly employed to date, does not seem to be quite satisfactory in this respect. Recent findings The… 

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The Draize eye test.

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The necessity of using animals to test whether new chemicals and products are eye irritants has been questioned with increasing frequency and fervor over the last 20 years but none of these nonanimal (in vitro) tests have become universally accepted as a complete replacement for the traditional rabbit (Draize) test.

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In vitro ocular irritation toxicity study of some pesticides.

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Bovine corneal opacity and permeability test: an in vitro assay of ocular irritancy.

The bovine corneal opacity and permeability assay allows investigation of two important components of eye irritation, in a one-day experiment, using an ocular tissue, and represents a useful approach to assess ocular irritation at least for the authors' needs.

The in vitro assessment of severe eye irritants.

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