Ocular toxicology: the Draize eye test

  title={Ocular toxicology: the Draize eye test},
  author={A. Secchi and V. Deligianni},
  journal={Current Opinion in Allergy and Clinical Immunology},
Purpose of review Superficial ocular tissues are frequently exposed to damage produced by chemical compounds applied on or around the ocular surface for cosmetic, therapeutic or accidental reasons. An experimental test measuring objectively and in a reproducible way any potential damaging effect would certainly help in prospectively minimizing unwanted effects. The Draize eye test, although commonly employed to date, does not seem to be quite satisfactory in this respect. Recent findings The… Expand
11 Citations
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  • Contact lens & anterior eye : the journal of the British Contact Lens Association
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Eye irritation of low-irritant cosmetic formulations: correlation of in vitro results with clinical data and product composition.
  • C. Debbasch, C. Ebenhahn, +4 authors G. Nohynek
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  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2005
In vitro ocular irritation toxicity study of some pesticides.
Reconstituted human corneal epithelium: a new alternative to the Draize eye test for the assessment of the eye irritation potential of chemicals and cosmetic products.
  • O. Doucet, M. Lanvin, +4 authors L. Zastrow
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  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2006
Bovine corneal opacity and permeability test: an in vitro assay of ocular irritancy.
The in vitro assessment of severe eye irritants.
Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay.
Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals.