Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir.

@article{Fresta2001OcularTA,
  title={Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir.},
  author={M. Fresta and G. Fontana and C. Bucolo and G. Cavallaro and G. Giammona and G. Puglisi},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 3},
  pages={
          288-97
        }
}
  • M. Fresta, G. Fontana, +3 authors G. Puglisi
  • Published 2001
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • Acyclovir-loaded polyethyl-2-cyanoacrylate (PECA) nanospheres were prepared by an emulsion polymerization process in the micellar phase and characterized. The influence of the presence of nonionic surfactant as well as other substances [i.e., 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) and poly(ethylene glycol) (PEG)], on formulation parameters and loading capacity was investigated. In particular, the presence of PEG resulted in an increase of mean size and size distribution. To obtain PEG… CONTINUE READING
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