Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation

@article{Burmeister1996OcularRM,
  title={Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation},
  author={Margit Burmeister and Jakub Nov{\'a}k and Mei-ying Liang and Sharmila Basu and Lynda A. Ploder and Norman L. Hawes and Danka Vidgen and Frank Hoover and Daniel Goldman and Vitauts I. Kalnins and Thomas H. Roderick and Benjamin A. Taylor and Mark H. Hankin and Roderick R. Mclnnes},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={376-384}
}
Ocular retardation (or) is a murine eye mutation causing microphthalmia, a thin hypocellular retina and optic nerve aplasia. Here we show that mice carrying the orJ allele have a premature stop codon in the homeobox of the Chx1O gene, a gene expressed at high levels in uncommitted retinal progenitor cells and mature bipolar cells. No CHX10 protein was detectable in the retinal neuroepithelium of orJ homozygotes. The loss of CHX10 leads both to reduced proliferation of retinal progenitors and to… CONTINUE READING
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