Ocular pigmentation protects the rabbit retina from gentamicin-induced toxicity.

@article{Zemel1995OcularPP,
  title={Ocular pigmentation protects the rabbit retina from gentamicin-induced toxicity.},
  author={Esther Zemel and Anat Loewenstein and Bo Lei and Moshe Lazar and Ido Perlman},
  journal={Investigative ophthalmology & visual science},
  year={1995},
  volume={36 9},
  pages={1875-84}
}
PURPOSE This study was designed to investigate the possibility that gentamicin-induced retinal toxicity is dependent on ocular pigmentation by comparing the effects of the drug on the functional and morphologic integrity of the retina in albino and pigmented rabbits. METHODS In each rabbit, a solution of gentamicin sulfate was injected into the vitreous of one eye, and saline was injected into the other eye. Retinal function was assessed by electroretinogram (ERG) at different time intervals… CONTINUE READING
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