Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.

@article{Proksch2010OcularPO,
  title={Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.},
  author={Joel W. Proksch and Keith W. Ward},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  year={2010},
  volume={26 5},
  pages={
          449-58
        }
}
  • J. Proksch, K. Ward
  • Published 6 October 2010
  • Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
PURPOSE The purpose of this investigation was to evaluate the ocular pharmacokinetic/pharmacodynamic (PK/PD) relationship for besifloxacin, moxifloxacin, and gatifloxacin using rabbit ocular PK data, along with in vitro minimum inhibitory concentration (MIC90) values against methicillin- and ciprofloxacin-resistant Staphylococcus aureus (MRSA-CR) and Staphylococcus epidermidis (MRSE-CR). METHODS Rabbits received a topical instillation of Besivance™ (besifloxacin ophthalmic suspension, 0.6… Expand
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Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery.
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