Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?

@article{Larakeb2007OcularII,
  title={Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?},
  author={Anis Skander Larakeb and Sandrine Leroy and V{\'e}ronique Fr{\'e}meaux-Bacchi and Marta Montchilova and B{\'e}atrice Pelosse and Olivier Dunand and Georges Desch{\^e}nes and Albert Bensman and Tim Ulinski},
  journal={Pediatric Nephrology},
  year={2007},
  volume={22},
  pages={1967-1970}
}
Factor H deficiency is responsible for thrombotic microangiopathy (TMA) via uncontrolled activation of the alternative pathway of the complement system. Ocular TMA has never been reported in patients with factor H abnormalities. A male patient with congenital homozygote factor H deficiency reached end-stage renal disease at the age of 10 years. Hemodialysis was uneventful for 3 years, when, suddenly, unilateral ocular pain and blurred vision occurred while he had febrile pharyngitis… CONTINUE READING