Ocular effects of adrenergic stereoisomers in the rabbit.

  title={Ocular effects of adrenergic stereoisomers in the rabbit.},
  author={Tseggai Gherezghiher and Michael C. Koss},
  journal={Journal of ocular pharmacology},
  volume={1 1},
Because of the need to develop ocular hypotensive agents with low incidence of side effects, the dextrorotatory enantiomers of adrenergic agents have prompted some attention. In the present study, the relative potency and efficacy of various adrenergic stereoisomers with respect to their ocular hypotensive and mydriatic effects have been determined after topical administration to conscious rabbits. The relative order of potency was found to be, iris: 1-epinephrine much greater than d… CONTINUE READING